diff --git a/mypy/checker.py b/mypy/checker.py
index fd4486218dc1..f030613fc6cc 100644
--- a/mypy/checker.py
+++ b/mypy/checker.py
@@ -5499,14 +5499,17 @@ def visit_operator_assignment_stmt(self, s: OperatorAssignmentStmt) -> None:
         self.try_infer_partial_generic_type_from_assignment(s.lvalue, s.rvalue, s.op)
         if isinstance(s.lvalue, MemberExpr):
             # Special case, some additional errors may be given for
-            # assignments to read-only or final attributes.
+            # assignments to read-only or final attributes. Also, the type used
+            # for writing (e.g. a property setter or descriptor __set__ type) may
+            # differ from the type used for reading.
             lvalue_type = self.expr_checker.visit_member_expr(s.lvalue, True)
+            read_type = self.expr_checker.accept(s.lvalue)
         else:
-            lvalue_type = self.expr_checker.accept(s.lvalue)
-        inplace, method = infer_operator_assignment_method(lvalue_type, s.op)
+            lvalue_type = read_type = self.expr_checker.accept(s.lvalue)
+        inplace, method = infer_operator_assignment_method(read_type, s.op)
         if inplace:
             # There is __ifoo__, treat as x = x.__ifoo__(y)
-            rvalue_type, _ = self.expr_checker.check_op(method, lvalue_type, s.rvalue, s)
+            rvalue_type, _ = self.expr_checker.check_op(method, read_type, s.rvalue, s)
             if not is_subtype(rvalue_type, lvalue_type):
                 self.msg.incompatible_operator_assignment(s.op, s)
         else:
diff --git a/test-data/unit/check-classes.test b/test-data/unit/check-classes.test
index b6eee21c50af..3b2d9ede14d6 100644
--- a/test-data/unit/check-classes.test
+++ b/test-data/unit/check-classes.test
@@ -9370,6 +9370,111 @@ a.foo = 1  # E: Incompatible types in assignment (expression has type "int", var
 reveal_type(a.foo)  # N: Revealed type is "builtins.int"
 [builtins fixtures/property.pyi]
 
+[case testPropertySetterTypeOperatorAssignment]
+from typing import Union
+
+class P:
+    def __iadd__(self, x: int) -> "P": ...
+class Q:
+    def __iadd__(self, x: int) -> "Q": ...
+
+class N:
+    @property
+    def a(self) -> P: ...
+    @a.setter
+    def a(self, v: P) -> None: ...
+
+    @property
+    def b(self) -> P: ...
+    @b.setter
+    def b(self, v: Union[P, Q]) -> None: ...
+
+    c: P
+
+    @property
+    def d(self) -> P: ...
+
+n = N()
+n.a += 1
+n.b += 1
+n.c += 1
+n.d += 1  # E: Property "d" defined in "N" is read-only
+n.a += ""  # E: Argument 1 to "__iadd__" of "P" has incompatible type "str"; expected "int"
+n.b += ""  # E: Argument 1 to "__iadd__" of "P" has incompatible type "str"; expected "int"
+[builtins fixtures/property.pyi]
+
+[case testPropertySetterTypeOperatorAssignmentInplaceMethodOnSetterType]
+class P:
+    def __iadd__(self, x: str) -> "P": ...
+class Q:
+    def __iadd__(self, x: int) -> "Q": ...
+
+class N:
+    @property
+    def a(self) -> P: ...
+    @a.setter
+    def a(self, v: Q) -> None: ...
+
+n = N()
+n.a += "x"  # E: Result type of + incompatible in assignment
+n.a += 1  # E: Result type of + incompatible in assignment \
+          # E: Argument 1 to "__iadd__" of "P" has incompatible type "int"; expected "str"
+[builtins fixtures/property.pyi]
+
+[case testPropertySetterTypeOperatorAssignmentNoInplaceMethod]
+class P:
+    def __add__(self, x: int) -> "P": ...
+class Q:
+    def __iadd__(self, x: int) -> "Q": ...
+
+class N:
+    @property
+    def a(self) -> P: ...
+    @a.setter
+    def a(self, v: P) -> None: ...
+
+    @property
+    def b(self) -> P: ...
+    @b.setter
+    def b(self, v: Q) -> None: ...
+
+n = N()
+n.a += 1
+n.b += 1  # E: Incompatible types in assignment (expression has type "P", variable has type "Q")
+[builtins fixtures/property.pyi]
+
+[case testDescriptorSetTypeOperatorAssignment]
+from typing import Any, Union, overload
+
+class P:
+    def __iadd__(self, x: int) -> "P": ...
+class Q: ...
+
+class Desc:
+    @overload
+    def __get__(self, obj: None, owner: Any) -> "Desc": ...
+    @overload
+    def __get__(self, obj: "M", owner: Any) -> P: ...
+    def __get__(self, obj: Union["M", None], owner: Any) -> Union[P, "Desc"]: ...
+    def __set__(self, obj: "M", v: Union[P, Q]) -> None: ...
+
+class Desc2:
+    @overload
+    def __get__(self, obj: None, owner: Any) -> "Desc2": ...
+    @overload
+    def __get__(self, obj: "M", owner: Any) -> P: ...
+    def __get__(self, obj: Union["M", None], owner: Any) -> Union[P, "Desc2"]: ...
+    def __set__(self, obj: "M", v: Q) -> None: ...
+
+class M:
+    d = Desc()
+    e = Desc2()
+
+m = M()
+m.d += 1
+m.e += 1  # E: Result type of + incompatible in assignment
+[builtins fixtures/property.pyi]
+
 [case testPropertyDeleterNoSetterOK]
 class C:
     @property